Pemphigus foliaceus is sometimes provoked by sun exposure.Įndemic pemphigus foliaceus occurs in South America, where it is commonly known as Fogo selvagem. In most cases, the autoantibodies are immunoglobulin type G ( IgG) but in IgA pemphigus, the autoantibodies are type A (IgA). Because the blister is very close to the surface of the skin, the blisters rupture easily. The result is the surface keratinocytes separate from each other, and are replaced by fluid: the blister. In pemphigus foliaceus, autoantibodies bind to a protein called desmoglein-1, which is found in desmosomes in the keratinocytes near the top of the epidermis. These cells are cemented together at special sticky spots called desmosomes. The building block cells of the epidermis are called keratinocytes. Pemphigus foliaceus is an autoimmune disorder, which basically means that an individual's immune systems starts reacting against his or her tissue. It appears most commonly between the ages of 50-60 years. Pemphigus foliaceus affects people of all races, age and sex.
USHER MEANING IN BENGALI SKIN
Blisters tend to form when the skin is rubbed ( Nikolsky sign). Pemphigus foliaceus is characterised by blistering lesions on otherwise healthy-looking skin. In New Zealand pemphigus foliaceus is more often encountered than its more serious relative pemphigus vulgaris, although worldwide pemphigus vulgaris is more common. Pemphigus foliaceus is a rare relatively benign form of pemphigus. The pemphigus family are rare autoimmuneblistering diseases affecting the skin and mucous membranes.
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